Effect of Remimazolam Use During Perioperative Period on Brain Waves and Postoperative Cognitive Function
Overview
- Phase
- N/A
- Intervention
- remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia
- Conditions
- Benzodiazepine
- Sponsor
- Yangzhou University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- The average intraoperative power spectral density in the frontal alpha band
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Benzodiazepine sedative hypnotics are commonly used intravenous anesthetics in clinical practice. Remimazolam is a new benzodiazepine with the characteristics of rapid onset, short maintenance and recovery time, no accumulation, metabolism independent of liver and kidney function, and no serious side effects, which has a good prospect for clinical application. Now we will study the effects of remimazolam on EEG and postoperative cognitive function ，in order to further understand the clinical application of remimazolam.
Investigators
Zhuan Zhang
Director
Yangzhou University
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing elective surgery under general anesthesia.
- •Age, sex, and weight were not limited.
Exclusion Criteria
- •Allergic or contraindication to remimazolam/midazolam/remifentanil;
- •Abnormal liver and kidney function; Alcohol abuse;
- •Long-term use of sedative, analgesic or anxiolytic drugs;
- •Hearing and language communication disorders;
- •Complicated with severe cardiovascular lesions or neurological diseases.
Arms & Interventions
Remimazolam 1
Intervention: remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia
Control
Intervention: control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1
Outcomes
Primary Outcomes
The average intraoperative power spectral density in the frontal alpha band
Time Frame: Preoperatively, During operation，End of operation
EEG data were collected at the beginning of the room admission, and the collection was ended at the end of the operation.
Changes in the score of MMSE
Time Frame: The outcome above should be measured the day before surgery and 1,2,3,5,7 days after surgery
The outcome above should be measured the day before surgery and 1,2,3,5,7 days after surgery
Secondary Outcomes
- Changes in IL-6, IL-10, and S100-β levels(The outcome above should be measured the day before surgery and 1，3 days after surgery)