Clinical trial to evaluate the Regorafenib therapy in patients with brain tumor progression after standard therapy (Radiotherapy + Temozolomide) with or without bevacizumab
- Conditions
- GlioblastomaMedDRA version: 17.1Level: PTClassification code 10018336Term: GlioblastomaSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)Therapeutic area: Diseases [C] - Cancer [C04]
- Registration Number
- EUCTR2014-003722-41-IT
- Lead Sponsor
- Istituto Oncologico Veneto – IOV-IRCCS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 112
•Male or female = 18 years of age
•Histologically confirmed de novo glioblastoma multiforme (grade IV)
•First recurrence after adjuvant treatment (surgery followed by radiotherapy and temozolomide chemotherapy with or without bevacizumab) in patients who have not received further therapeutic interventions
•Documented progression of disease as defined by RANO criteria at least 12 weeks after completion of radiotherapy, unless the recurrence is outside the radiation field or has been histologically documented
•Have adequate bone marrow function, liver function, and renal function, as measured by the following laboratory assessments conducted within 7 days prior to the initiation of study treatment:
-Hemoglobin >9.0 g/dl
-Absolute neutrophil count (ANC) >1500/mm3 without transfusions or granulocyte colony stimulating factor and other hematopoietic growth factors
-Platelet count ?100,000/µl
-WBC >3.0 x 109/L
-Total bilirubin <1.5 times the upper limit of normal
-ALT and AST <3 x upper limit of normal (<5 x upper limit of normal for patients with liver involvement of their cancer and/or have bone metastasis)
-Serum creatinine <1.5 x upper limit of normal
-Alkaline phosphatase <2.5 x ULN (<5 x upper limit of normal for patients with liver involvement of their cancer and/or have bone metastasis)
-PT-INR/PTT <1.5 x upper limit of normal (Patients who are being therapeutically anticoagulated with an agent such as coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists per medical history)
-Lipase = 1.5 x the ULN
•Glomerular filtration rate ? 30 mL/min/1.73 m2 according to the Modified Diet in Renal Disease abbreviated formula
•Analyses of MGMT methylation status on tumoral tissue at first surgery (at own institution)
•Understand, be willing to give consent, and sign the written informed consent form (ICF) prior to undergoing any study-specific procedure
•If female and of childbearing potential, have a negative result on a pregnancy test performed a maximum of 7 days before initiation of study treatment
•If female and of childbearing potential, or if male, agree to use adequate contraception (eg, abstinence, intrauterine device, oral contraceptive, or double-barrier method) based on the judgment of the investigator or a designated associate from the date on which the ICF is signed until 8 weeks after the last dose of study drug
•WHO Performance status = 1 (or KPS =70) within 14 days prior to the initiation of study treatment
•Stable or decreasing dosage of steroids for 7 days prior to the baseline MRI scan.
•Patients may have undergone surgery for the recurrence; the histological report must document a glioblastoma recurrence. If operated:
-at least 28 days and maximum 42 days interval from the surgery is required prior to administration of study drugs and patients should have fully recovered
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 39
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 73
•Are taking strong cytochrome P (CYP) CYP3A4 inhibitors (eg, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, voriconazole) or strong CYP3A4 inducers (eg, carbamazepine, phenobarbital, phenytoin, rifampin, St. John’s Wort)
•Radiotherapy within 12 weeks prior to the diagnosis of progression
•Have had systemic anticancer therapy including cytotoxic therapy, signal transduction inhibitors, immunotherapy, and/or hormonal therapy within 4 weeks prior to initiation of study treatment
•Positioning of carmustin wafers during first or second surgery
•Other active or inactive malignancy (except for carcinoma in situ of the cervix, of the prostate or basal cell carcinoma). Malignancy will be considered inactive if patients are in complete remission for at least 3 years prior to study entry
•Have had prior treatment with regorafenib or any other VEGFR-targeting kinase inhibitor
•Have had a major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to initiation of study treatment
•Are pregnant
•Are breastfeeding
•Are unable to swallow oral tablets (crushing of study treatment tablets is not allowed)
•Have congestive heart failure classified as New York Heart Association Class 2 or higher
•Have had unstable angina (angina symptoms at rest) or new-onset angina ? 3 months prior to screening.
•Have had a myocardial infarction < 6 months prior to initiation of study treatment
•Have cardiac arrhythmias requiring anti-arrhythmic therapy, with the exception of beta blockers or digoxin
•Have uncontrolled hypertension (systolic blood pressure [SBP] > 140 mmHg or diastolic blood pressure [DBP] > 90 mmHg) despite optimal medical management
•Have had arterial thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks), or pulmonary embolism within 6 months prior to the initiation of study treatment
•Have an ongoing infection with severity of Grade 2 or above (NCI-CTCAE v 4.0)
•Have a known history of human immunodeficiency virus infection
•Have either active or chronic hepatitis B or C requiring treatment with antiviral therapy
•Have a history of organ allograft
•Have evidence or history of any bleeding diathesis (including mild hemophilia), irrespective of severity
•Have had a hemorrhage or a bleeding event ? Grade 3 (NCI-CTCAE v 4.0) within 4 weeks prior to the initiation of study treatment
•Have a non-healing wound, ulcer, or bone fracture
•Have renal failure requiring hemodialysis or peritoneal dialysis
•Have dehydration ? Grade 1 (NCI-CTCAE v 4.0)
•Have interstitial lung disease with ongoing signs and symptoms at the time informed consent is obtained
•Have persistent proteinuria > 3.5 g/24 hours measured by urine protein creatinine ratio from a random urine sample (? Grade 3, NCI-CTCAE v 4.0)
•Have any other serious or unstable illness, or medical, psychological, or social condition, that could jeopardize the safety of the subject and/or his/her compliance with study procedures, or may interfere with the subject’s participation in the study or evaluation of the study results
•Have a known hypersensitivity to any of the study drugs, study drug classes, or excipients in the formulation of the study drugs
•Have any malabsorbition condition
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method