The Effect of Probiotics on Cognition and Gut Microbiome Associated Study of Shanghai People With Acute Ischemic Stroke
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- change from admission on gut microbiome at 3months by genome sequencing
研究概览
简要总结
The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of ischemic stroke patients.
详细描述
This study aims to detect the impact of probiotics administration during the process of ischemic stroke treatment and recovery phase. The day of admission and 3months after stroke data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the stroke patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients diagnosed with acute ischemic stroke on the basis of World Health Organization diagnostic criteria
- •the time from paroxysm to admission ≤2weeks.
排除标准
- •Imaging diagnoses hemorrhagic stroke Severe depression Severe disturbance of hearing vision and reading Illiteracy Have recognitive disorder before stroke (recorded in medical records) Treated with antibiotics probiotics or prebiotics in1month before admission
研究组 & 干预措施
No Intervention
the patients in this arm will not receive probiotics.
Experimental
the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus for 3 months.
干预措施: Probiotics (Dietary Supplement)
结局指标
主要结局
change from admission on gut microbiome at 3months by genome sequencing
时间窗: 3months
change of the gut microbiome will be calculated at 3months in comparison with admission.
次要结局
- change from admission on cognitive function at 3months by Montreal Cognitive Assessment.(3months)
- change from admission on emotion at 3months by Hamilton Depression Scale.(3months)
研究者
Huanlong Qin
DIRECTOR
Shanghai 10th People's Hospital