PLAIAR-Trial: Platelets in Inflammation and Resolution

• Conditions: ARDS; Platelet Abnormality

• Registration Number: NCT05098106
• Lead Sponsor: University Hospital Muenster

Brief Summary

Detection and determination of platelets in bronchoalveolar lavage fluid and blood in ARDS and non-ARDS-patients. Correlation with phenotype and inflammation parameters in blood and outcome parameters.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-01
• Status Verified: 2021-10
• Study First Submitted: 2021-10-18
• Study First Submitted QC: 2021-10-18
• Study First Posted: 2021-10-28
• Last Update Submitted: 2021-11-02
• Last Update Posted: 2021-11-10
• Primary Completion: 2023-03
• Study Completion: 2023-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• Routine bronchoscopy
• Patient in perioperative setting
• Age >=18 years
• Consent

Exclusion Criteria

• Active or recent (in past 7 days) bleeding in upper airways
• Recent traumatic injury of the lung associated with (micro-)hemorrhage
• Blood aspiration
• Pregnancy
• Age<18 years
• Acute kidney injury / Chronic kidney failure / Dialysis
• Transplantation
• HIV
• Hematologic diseases
• Immunosuppression
• Anti-Platelet-Therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detectability and changes in platelets in BAL and blood	5-7 days
Organ failure, survival.	1 Year
Systemic platelet and leukocyte numbers	5-7 days
Systemic platelet and leukocyte phenotypes.	5-7 days
Systemic cytokine profiles.	5-7 days

Trial Locations

Locations (1)

University Hospital Muenster; 🇩🇪 Muenster, Germany