PLAIAR-Trial: Platelets in Inflammation and Resolution
- Conditions
- ARDSPlatelet Abnormality
- Interventions
- Diagnostic Test: Bronchoscopy, blood sampling; testing.
- Registration Number
- NCT05098106
- Lead Sponsor
- University Hospital Muenster
- Brief Summary
Detection and determination of platelets in bronchoalveolar lavage fluid and blood in ARDS and non-ARDS-patients. Correlation with phenotype and inflammation parameters in blood and outcome parameters.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- Routine bronchoscopy
- Patient in perioperative setting
- Age >=18 years
- Consent
Exclusion Criteria
- Active or recent (in past 7 days) bleeding in upper airways
- Recent traumatic injury of the lung associated with (micro-)hemorrhage
- Blood aspiration
- Pregnancy
- Age<18 years
- Acute kidney injury / Chronic kidney failure / Dialysis
- Transplantation
- HIV
- Hematologic diseases
- Immunosuppression
- Anti-Platelet-Therapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Pneumonia patients with ARDS Bronchoscopy, blood sampling; testing. Patients in the perioperative/intensive care setting with pneumonia-induced ARDS requiring bronchoscopy. Ventilated patients without ARDS Bronchoscopy, blood sampling; testing. Patients without ARDS on mechanical ventilation.
- Primary Outcome Measures
Name Time Method Detectability and changes in platelets in BAL and blood 5-7 days Organ failure, survival. 1 Year Systemic platelet and leukocyte numbers 5-7 days Systemic platelet and leukocyte phenotypes. 5-7 days Systemic cytokine profiles. 5-7 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Muenster
🇩🇪Muenster, Germany