Hypovitaminosis D Prediction Score

Not Applicable

Completed

Interventions: Biological: Blood sampling
Other: self-administered questionnaire

Brief Summary: Vitamin D has effects on many tissues, and hypovitaminosis D is frequent. In a French survey conducted among 1587 adults, vitamin D insufficiency (\<30ng/ml) has been reported in 80% of subjects, including 43% with moderate deficiency (\<20ng/ml) and 5% with severe deficiency (\<10ng/ml).

Because of the possible consequences of hypovitaminosis D (osteomalacia in adults...), the number of vitamin D determination has increased ten-fold since 2005 in France, reaching 4.5 million € in 2011, and with it the costs for health insurance. However, there is currently no consensus on the strategy for detection, diagnosis and treatment of hypovitaminosis D.

We propose to develop a predictive clinical score of hypovitaminosis D based on the accurate assessment of solar exposure, vitamin D intakes and hypovitaminosis D risk factors collected through a self-administered questionnaire.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Participation in a study related to vitamin D
Taking at least 80 000 IU vitamin D in the last 3 months as a single dose
Pregnancy or breast-feeding
Renal failure : severe renal impairment, dialysis, having kidney transplant
Known hepatic impairment
Gastrointestinal disorders: Celiac disease, Crohn's disease, ulcerative colitis, bariatric surgery, gastrointestinal surgery with stoma
Known primary hypo/hyperparathyroidism
Bone cancer/metastases current or in the last 2 years
Treatment with antiepileptics
Long-term treatment with glucocorticoids (> 3 months)
Treatment with antiretroviral
Legal incapacity or limited legal capacity
Non-recipient of French Social Security

Arm && Interventions

Group	Intervention	Description
Vitamin D status	Blood sampling	The 2500 subjects included in this unique arm will complete a self-administered questionnaire and will have a blood sampling to measure vitamin D blood concentration.
Vitamin D status	self-administered questionnaire	The 2500 subjects included in this unique arm will complete a self-administered questionnaire and will have a blood sampling to measure vitamin D blood concentration.

Primary Outcome Measures

Name	Time	Method
25 (OH) vitamin D blood concentration	The day of inclusion	Vitamin D determination will be carried out for each center in a single laboratory by chemiluminescence technique. Vitamin D determination is the gold standard for the development and validation phases of the score. It will define the variables of the self-administered questionnaire to be included in the final score (development phase) and be the gold standard in the evaluation of the performance score (validation phase). The blood sample will be collected after the completion of the questionnaire, on the same day.

Secondary Outcome Measures

Name	Time	Method
Vitamin D concentration level	The day of inclusion	The ability of the score to classify adults in one of these three categories: * Category 1 : Vitamin D sufficiency (≥30 ng/ml) * Category 2 : Hypovitaminosis D between 30 and 10 ng/ml * Vitamin D insufficiency (\<30 ng/ml) * Vitamin D deficiency (\<20 ng/ml) * Category 3 : Severe deficiency (\<10 ng/ml)

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