ISRCTN60045220进行中（未招募）4 期
A randomised trial examining therapy to maintain remission in dilated cardiomyopathy
适应症
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. A diagnosis of DCM
- •2. Previous LVEF <40% (on echocardiography or cardiovascular magnetic resonance [CMR])
- •3. Current LVEF >50% for at least 6 months duration with normal left ventricular end-diastolic volume (LVEDV) at inclusion
- •4. Plasma NT-pro-BNP<250ng/L
- •5. New York Heart Association (NYHA) class I
- •6. Sinus rhythm
- •7. Taking a beta-blocker and an ACEi, ARB or sacubitril-valsartan, along with at least one of an MRA or SGLT2i.
排除标准
- •1. Current atrial fibrillation
- •2. Prior sustained ventricular tachycardia or fibrillation
- •3. A known likely pathogenic or pathogenic variant in LMNA/DSP/FLNC/RBM20
- •4. Sudden cardiac or heart failure death in a first degree relative <50 years
- •5. Contraindication to CMR
- •6. Estimated glomerular filtration rate (eGFR) <45mls/min
- •7. Current or planned pregnancy
- •8. Known active myocardial inflammation
- •9. Another indication for an SGLT2i (diabetes mellitus or CKD)
- •10. Previous relapse of symptomatic heart failure following initial recovery in function
- •11. Current participation in another CTIMP
- •12. Ongoing need for other heart failure therapies including loop diuretics, ivabradine or digoxin
研究者
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