Effect of influenza vaccination on level of phenytoin in Thai epileptic patients treated with phenytoi

Not Applicable

• Conditions: Epileptic patients treated with Phenytoin; Influenza vaccine, Epilepsy, Phenytoin

• Registration Number: TCTR20181007001
• Lead Sponsor: Faculty of Medicine endowment Fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-07
• Study Completion: 2019-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Epilepsy age 18-55 years
2. Treated with Phenytoin monotherapy

Exclusion Criteria

1. Contraindication of vaccine
2. Liver disease
3. Concomitant drugs that have effect on CYP2C9/2C19
4. Active infection or got infected within 2 weeks

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Phenytoin level, interferon-𝛾, oxidative enzyme(CYP2C9) day 0,1,4,7,14 chemiluminescent microparticle immunoassay(CMIA), Enzyme-linked immunosorbent assay (ELISA)

Secondary Outcome Measures

Name	Time	Method
Adverse events during study interview