Acupuncture as a disease modifying therapy for the treatment in remission stage of neuromyelitis optics spectrum disorders
- Conditions
- euromyelitis optics spectrum disorders of remitting stageNervous System DiseasesNeuromyelitis optics spectrum disorders of remitting stage
- Registration Number
- ISRCTN92125844
- Lead Sponsor
- Beijing Traditional Chinese Medical Hospital Affiliated to Capital Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
1. Diagnosis of neuromyelitis optics spectrum disorders in accordance with NMOSDs diagnostic criteria established by the international panel for NMO diagnosis (IPND) in 2015.
2. In remission stage (no acute progress, no corticosteroid therapy or immunoglobulin therapy, plasma exchange, stable condition without relapse signs)
3. Age of 18-75 years old
4. EDSS score less than 5
5. No other treatment with immunosuppressive drugs within 6 months or no other immunosuppressive drugs other than azathioprine
6. Provision of informed consent
1. Oral azathioprine intolerant patients
2. History of severe allergies
3. Those who can not tolerate acupuncture
4. Clinically significant history of disease, blood disease, endocrine, metabolism, liver, lung, urinary system, nervous system, skin disease, other major primary disease and psychiatric disease
5. Malignant tumor
6. B type hepatitis
7. Pregnancy or lactation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disability is measured using the Expanded disability scale score at baseline, 3, 6 and 12 months.
- Secondary Outcome Measures
Name Time Method 1. AQP4-IgG level is measured using cell transfection method at baseline and 3 months<br>2. Annual relapse rate is measured using computer formula at baseline, 3, 6 and 12 months