Comparison of Effects of 3 Different PEEP Levels on Hemodynamic, Respiratory Mechanics and Elimination of Volatile Anesthetic Agent in Patients Undergoing Laparoscopic Cholecystectomy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- levels of static-dynamic compliance with intra-operative PEEP treatment at 3 distinct levels
Study Overview
Brief Summary
Laparoscopic cholecystectomy is accepted as gold standard in the management of cholelithiasis. Although laparoscopic procedures have many advantages,intra-abdominal CO2 insufflation can cause decreased lung volumes and compliance, increased airway resistance and impaired ventilation-perfusion ratio. In this study, investigators aim to investigate effects of intra-operative PEEP treatment at 3 distinct levels on respiratory dynamics and elimination time of volatile anesthetic agent.
Detailed Description
In the study, 75 ASA I-II patients aged 30-65 years will be randomized into 3 groups to receive 0 cmH2O PEEP (Group-1), 5 cmH2O PEEP (Group-2) and 8 cmH2O PEEP (Group-3) in PVC mode. In all patients underwent general anesthesia; hemodynamic parameters, Ppeak, Pplateau, compliance values as well as Fisevo/Fexpsevo ratio at 1 MAC and times from 1 MAC to 0.3 and 0.1 MAC will be recorded. In addition, preoperative and postoperative pulmonary function tests will be compared in all patients.
Study Design
- Study Type
- Observational
- Observational Model
- Case Crossover
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 30 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ASA (American Society of Anesthesiologists) I-II
- •BMI of 25-30
- •patients scheduled to elective laparoscopic cholecystectomy.
Exclusion Criteria
- •Patients with ASA III, IV, V risk,
- •Patients with comorbid diseases that may increase intra-abdominal pressure or pulmonary hypertension,
- •Patients with renal and hepatic failure,
- •Patients with pregnancy and
- •Patients using bronchodilator or steroid were excluded.
Outcomes
Primary Outcomes
levels of static-dynamic compliance with intra-operative PEEP treatment at 3 distinct levels
Time Frame: 1 month
Secondary Outcomes
- levels of p peak and p plateau pressures with intra-operative PEEP treatment at 3 distinct levels(1 month)
- elimination time of volatile anesthetic agent with intra-operative PEEP treatment at 3 distinct levels(1 month)
Investigators
Gulsah Karaoren
MD
Umraniye Education and Research Hospital