The Effect of Vitamin D status on Fracture healing - a prospective cohort study

Completed

• Conditions: Fracture healing; delayed union; 10017322

• Registration Number: NL-OMON42821
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

- Age 18 -50 years
- Extra-articular fracture of the clavicle, humerus, fore arm, metacarpalia, femur, lower leg or metatarsalia.
- Initial X-ray;s
- Inclusion within 10 days after trauma

Exclusion Criteria

Refracture, pathological fracture, complicated fracture.
Use of vitamin D or glucocorticosteroids

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Delayed union, defined as incomplete consolidation (clinically and<br /><br>radiologically) after 4 months. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Non-union, defined as absent fracture consolidation after 9 months<br /><br>- Complications during fracture healing (infection, mal-Union, refracture,<br /><br>(re)operation).<br /><br>- Perceived pain<br /><br>- Functional recovery<br /><br>- Quality of life<br /><br>- Costs.<br /><br>- Natrium, potasium, kreatinin, calcium, phosfor, PTH, alkaline phosphatase,<br /><br>CTX en PINP</p><br>