Anatomical Resection in Colorectal Liver Metastases Patients

Completed

• Conditions: The Characteristics of CRLM Patients Who Would Benefit More From Anatomical Resection
• Interventions: Procedure: Anatomical Resection

• Registration Number: NCT05673564
• Lead Sponsor: Fudan University

Brief Summary

The type of liver resection (anatomical resection, AR or nonanatomical resection, NAR) for colorectal liver metastases (CRLM) is subject to debate. The debate may persist because some certain prognostic factors, associated with aggressive biological behavior of tumor, have been overlooked. The aim of our study was to investigate the characteristics of patients who would benefit more from anatomical resection for colorectal liver metastases.

Detailed Description

729 patients who underwent hepatic resection of CRLM were retrospectively collected from June 2012and May 2019. Treatment effects between AR and NAR were compared in full subgroup analyses. Tumor relapse-free survival (RFS) was evaluated by a stratified log-rank test and summarized with the use of Kaplan-Meier and Cox proportional hazards methods.

Study Timeline

• Study Start: 2012-06-01
• Primary Completion: 2019-05-01
• Study Completion: 2019-05-01
• Status Verified: 2023-01
• Study First Submitted: 2023-01-04
• Study First Submitted QC: 2023-01-04
• Last Update Submitted: 2023-01-04
• Study First Posted: 2023-01-06
• Last Update Posted: 2023-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 729

Inclusion Criteria

(1)Age 18-79 years;(2) Histologically proven colorectal adenocarcinoma;

Read More

Exclusion Criteria

(1) the histologic type of tumor was not called adenocarcinoma; (2) peritoneal metastasis; (3) number of liver metastasis >3; (4) simultaneous anatomical and nonanatomical resections; (5) R2 resection; (6) history of previous hepatectomy; (7) incomplete data. The rest of patients were divided into 2 groups: patients undergoing an AR, and patients undergoing a NAR.

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
anatomical resection group	Anatomical Resection	Anatomical resection was defined as resection of 1 or more complete hepatic segments in our study, including bisegmentectomy, right hemihepatectomy, left hemihepatectomy, extended right hemihepatectomy, extended left hemihepatectomy, single segmentectomy, caudate lobectomy, or a combination of these.

Primary Outcome Measures

Name	Time	Method
RFS	2012.6.1-2022.6.1	Relapse-free survival since patients undergoing hepatic resection

Secondary Outcome Measures

Name	Time	Method
OS	2012.6.1-2022.6.1	Overall survival since patients undergoing hepatic resection