Artificial Endometrial Preparation for Frozen Thawed Embryo Transfer Applying Either Endometrin or Utrogestan
- Conditions
- Frozen Thawed Embryo Transfer
- Registration Number
- NCT00345306
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
The transfer of frozen-thawed embryos can be performed in a natural ovulatory cycle or in a hormonally manipulated cycle with a comparable pregnancy rate of 15%-20% per ET. When a hormonally modulated ET cycle is scheduled,an artificial endometrial preparation is carried out using estrogen stimulation followed by a concomitant progesterone treatment. Two progestative drugs are currently used in conventional IVF treatment, Utrogetan and Endometrin. Although Endometrin has been be efficiently used to support the luteal phase after embryo transfer in IVF cycles, currently, there is no study that assess its efficacy for clinical use in frozen-thawed ET cycles. The present study aims to compare the outcome of frozen thawed ET cycles when either Endometrin or Utrogestan are used as the progestative substitution in an artificially prepared endometrium.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- Female
- Target Recruitment
- 120
- Patients undergoing frozen thawed ET cycles
- Patient has at least two embryos suitable for transfer after thawing
- Age 18-35 years -
- Any known sensitivity to Endometrin or Utrogestan
- Endometrial thickness less than 7.5 mm after estrogen priming -
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pregnancy rates
- Secondary Outcome Measures
Name Time Method Lutheal hormonal profile
Trial Locations
- Locations (2)
Simon Alex
🇮🇱Jerusalem, Israel
Hadassah Medical Organization
🇮🇱Jerusalem, Israel