跳至主要内容
临床试验/NCT06707948
NCT06707948尚未招募不适用

Comparison of Different Treatment Strategies for Root Injury Behind the Medial Meniscus to Delay the Progression of Knee Osteoarthritis: a Prospective Cohort Study

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine0 个研究点目标入组 69 人开始时间: 2024年11月30日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
69
主要终点
the incidence of KOA

研究概览

简要总结

Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. Early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. Based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining Magnetic Resonance Imaging(MRI) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. This is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
50 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Clinical diagnosis of posterior root tear of the medial meniscus;
  • Patients with K-L classification ≤ grade II;
  • The age range of 50-65 years old;
  • International Cartilage Repair Society (ICRS) Modified Magnetic Resonance Imaging Grading System ≤ Grade 2;
  • International Cartilage Repair Society (ICRS) arthroscopic grading system ≤ grade 2;
  • Knee joint mobility ≥90°;
  • Inversion deformity ≤10°;
  • Must be able to complete follow-up MRI within 2 years after knee meniscus surgery;
  • Must be able to complete clinical data;

排除标准

  • Can not participate in this study;
  • Patients with concomitant meniscal injuries elsewhere;
  • knee joint infection disease;
  • Osteoporosis disease;
  • Patients with previous history of knee surgery;
  • Knee joint instability disease;
  • Severe KOA disease;
  • Can not cooperate with MRI detection;
  • Cannot tolerate the surgery;
  • Those who cannot tolerate the arthroscopic knee surgery;
  • Neuromuscular system pathology disease;

结局指标

主要结局

the incidence of KOA

时间窗: 30th November 2024 -30th November 2027

次要结局

  • Articular cartilage T2-mapping value(30th November 2024 -30th November 2027)

研究者

发起方
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
申办方类型
Other
责任方
Principal Investigator
主要研究者

Yinxian Yu

Associate Professor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

相似试验