DRKS00030602招募中4 期

Randomized clinical pilot study investigating the effect of Lactobacillus reuteri on subgingival biofilm formation on healing abutments and inflammatory status of surrounding peri-implant tissues - Effect of probiotics on peri-implant biofilm

Clinic of Conservative and Preventive Dentistry University of Zurich, Center of Dental Medicine0 个研究点目标入组 28 人开始时间: 2022年10月26日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Patients requiring a single implant in the posterior area (premolars and molars, maxilla or mandible) with a single-tooth supported crown
•Patients 18 to 90 years of age
•no active periodontitis as determined by no PPD =6mm or no periodontitis, as determined by a PSI score of =2
•a full-mouth plaque score and full-mouth bleeding score <25% as recorded at 6 sites per tooth
•= 4 months post extraction
•Signed Informed Consent after being informed

•general medical condition, which represents a contraindication for implant treatment
•Systemic or local disease or condition that can compromise healing or osseointegration
•History of radiation in head-neck area
•current pregnancy (captured through inquiry)
•>10 Cigarettes daily
•Diabetes mellitus with an HbA1c > 7
•antibiotic therapy within the last = 4 weeks
•use of orally applied antibacterial products
•use of probiotic supplements
•use of anti-inflammatory drugs
•Use of drugs influencing bone metabolism
•marginal bone augmentation during implantation
•attached horizontal tissues =2mm after implantation
•Known or suspected non-compliance, drug or alcohol abuse
•Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
•Participation in another study with investigational drug within the 30 days preceding and during the present study,
•Previous enrolment into the current study
•Enrolment of the investigator, his/her family members, employees and other dependent persons

发起方

Clinic of Conservative and Preventive Dentistry University of Zurich, Center of Dental Medicine