Effect of Pressure Support Ventilation During Anesthetic Emergence on Postoperative Atelectasis in Infant

Not Applicable

• Conditions: Infants Aged 0 Days to 13 Months Scheduled for Elective Surgery
• Interventions: Other: pressure support, group PS; Other: conventional ventilation, group C

• Registration Number: NCT05373589
• Lead Sponsor: Yonsei University

Brief Summary

Atelectasis occurs in patients of all ages who receive mechanical ventilation under general anesthesia, and although fatal cases are rare, it is known as a cause of postoperative hypoxia or fever. In pediatric patients, it has a particularly high incidence of 68-100%, and the incidence is inversely proportional to age. Pediatric patients,compared to adults, have a small capacity for functional residual capacity while a high metabolic demand, making them fundamentally vulnerable to hypoxia. Increased atelectasis during anesthesia causes hypoxia not only during anesthesia but also during recovery after anesthesia. Therefore, it is important to establish and apply a strategy to minimize the occurrence of atelectasis during mechanical ventilation under general anesthesia in pediatric patients. The aim of this study is to investigate whether pressure support ventilation at emergence period could reduce the incidence of postoperative atelectasis in infants undergoing surgery under general anesthesia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-04-29
• Status Verified: 2022-05
• Study Start: 2022-05
• Study First Submitted QC: 2022-05-09
• Last Update Submitted: 2022-05-09
• Study First Posted: 2022-05-13
• Last Update Posted: 2022-05-13
• Primary Completion: 2023-02
• Study Completion: 2023-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 136

Inclusion Criteria

1. infant patients aged 0 day to 13 month
2. American Society of Anesthesiologists (ASA) classification 1~2 who are scheduled for elective surgery under general anesthesia

Exclusion Criteria

1. patients with symptomatic bronchopulmonary dysplasia
2. patients with uncorrected congenital heart or pulmonary disease
3. Hemodynamically unstable requiring preoperative vasopressor administration
4. fever (>37.5°) or URI symptoms on the day of surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group PS	pressure support, group PS	-
group C	conventional ventilation, group C	-

Primary Outcome Measures

Name	Time	Method
Frequency of atelectasis	Within 5 minutes of arriving at the recovery room	Immediately after arriving at the recovery room, lung ultrasound is performed to check for atelectasis.

Secondary Outcome Measures

Name	Time	Method
Frequency of atelectasis	After 30 minutes of stay in the recovery room	After 30 minutes of staying in the recovery room, lung ultrasound was performed to check for atelectasis.
scoring of atelectasis	at the time of admission and after 30 minutes of stay in the recovery room	Perform atelectasis scoring on 12 parts of the lung
Frequency of desatuation	at the time of admission and after 30 minutes of stay in the recovery room	Check the frequency of desaturation (\<95%) during the stay in the recovery room.

Trial Locations

Locations (1)

Yonsei University Health System, Severance Hospital; 🇰🇷 Seoul, Korea, Republic of