Adipokines Effect in Myometrial Contractility
- Conditions
- Myometrium; ContractilityGDMObesity
- Registration Number
- NCT03505541
- Lead Sponsor
- University of Minnesota
- Brief Summary
Investigate the effect of two adipokines which are adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 60
- Pregnant patients scheduled for a CS at 37-41 weeks of gestation at M Health Birth Place
- Participants age ≥18.
- Full informed consent able to be provided by the participant.
- Patients undergoing general anesthesia for their CS.
- Pre-gestational DM, and DM diagnosed <24 weeks gestation.
- Patients unable to consent for themselves
- Multiple gestation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect on force of contractility 24 hours Determine the effect of adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery
- Secondary Outcome Measures
Name Time Method Progesterone effect in control group 24 hours Investigate the anti-inflammatory properties of Progesterone (P4) and 17a-Hydroxyprogesterone (HPC) on Adiponectin induced myometrial contractility in control group
Force of contractility between study groups 24 hours Compare the force of myometrial contractility in study groups compared to control group (non-DM, non-obese term pregnant patients)
Related Research Topics
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Trial Locations
- Locations (1)
Fairview Hospital
🇺🇸Minneapolis, Minnesota, United States
Fairview Hospital🇺🇸Minneapolis, Minnesota, United States