Sepsis Prediction by Monocyte Distribution Width and Procalcitonin

• Conditions: Diagnoses Disease; Sepsis
• Interventions: Diagnostic Test: Monocyte Distribution Width

• Registration Number: NCT04322942
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

The mortality rate of sepsis remains as high as 30 to 40%. Early diagnosis and treatment of patients with sepsis reduce mortality significantly. The most commonly used biomarkers in clinical practice are C-reactive protein (CRP) and procalcitonin (PCT). In terms of exploring new diagnostic tools of sepsis, monocyte distribution width (MDW) was first reported in 2017. It was reported as part of the white blood cell (WBC) differential count. MDW greater than 20 and abnormal WBC count together were reported to provide a satisfactory accuracy. The area under curve (AUC) in predicting sepsis-2 is 0.852. It was proposed as a novel diagnostic tool of sepsis in the emergency setting. Nonetheless, the performance of MDW compared with the conventional biomarkers remained unknown. The aim of this study was to compare the diagnostic accuracy of MDW and PCT on sepsis in the emergency department.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-16
• Status Verified: 2020-03
• Study First Submitted: 2020-03-22
• Study First Submitted QC: 2020-03-25
• Last Update Submitted: 2020-03-25
• Study First Posted: 2020-03-26
• Last Update Posted: 2020-03-26
• Primary Completion: 2020-09-30
• Study Completion: 2020-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sepsis-3	Monocyte Distribution Width	-
Non-infection	Monocyte Distribution Width	-
Infection without sepsis	Monocyte Distribution Width	-
Sepsis-2	Monocyte Distribution Width	-

Primary Outcome Measures

Name	Time	Method
Sensitivity and specificity of predicting sepsis and sepsis-3 patients	within 2 hours after patient arrived ED.	MDW, PCT, and other laboratory tests were all obtained at the same time with 2 hours after the patient was admitted to the emergency department (ED). Sensitivity and specificity of different cutoff value were calculated. Best cutoff value will be decided by the perfomance.

Trial Locations

Locations (1)

Chang Gung Memorial Hospital, Linkou Medical Center; 🇨🇳 Taoyuan, 新北市, Taiwan