Cognitive deficit in first time CABG patients receiving Lidocaine versus procaine hydrochloride as an additive to the cardioplegia solutio
- Conditions
- Cognitive function after CABG surgery.Psychological and behavioural factors associated with disorders or diseases classified elsewhere
- Registration Number
- IRCT201104224365N8
- Lead Sponsor
- Vice chancellor for research of Mazandaran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 110
Informed written consent; Elective CABG surgery; Age between 20 and 70 years; Use of the cardiopulmonary pump during surgery.
Exclusion criteria: History of symptomatic cerebrovascular disease; Alcohol use (> 50 cc /day); History of psychiatric illness (any clinical diagnosis requiring therapy); History of drug abuse (any illicit drug abuse in the past 3 months); Hepatic insufficiency (liver function tests > 1.5 times of the normal upper limit); Sever pulmonary insufficiency (requiring home oxygen therapy); Renal failure (baseline serum creatinine > 2mg/dl); Lack of cooperation in response to cognitive test; together with other cardiac surgery (valvular surgery); History of previous cardiac surgery; Ejection fraction < 35%; history of sensitivity to lidocaine or procaine hydrochloride.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive function. Timepoint: The day before, 10 days and 2 month after operation. Method of measurement: Folstein Neurocognitive Test.
- Secondary Outcome Measures
Name Time Method Cardiac Dysrrhythmia. Timepoint: Before trial, during the operation and three days later. Method of measurement: Cardiac monitoring.;Serum lidocaine level. Timepoint: 10 min before CPB, 10 and 60 min after CPB. Method of measurement: Laboratory kit.