A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study of Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection in Patients With High Risk of Relapse After Radical Surgery or Ablation of Hepatocellular Carcinoma (HCC).
Overview
- Phase
- Phase 3
- Intervention
- Anlotinib hydrochloride capsules, Penpulimab injection
- Conditions
- Hepatocellular Carcinoma
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Enrollment
- 480
- Locations
- 67
- Primary Endpoint
- Recurrence-free survival (RFS)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The primary objective of this study was to evaluate the efficacy of anlotinib hydrochloride capsules combined with penpulimab injection (test group) versus placebo (control group) for adjuvant therapy after radical surgery or ablation in HCC patients with high risk of recurrence by assessing recurrence-free survival (RFS).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age: 18-75 years old; Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≤ 1; Predicted survival ≥12 weeks.
- •Subjects with hepatocellular carcinoma (HCC) confirmed by histopathology or cytology or who meet the diagnostic criteria for Primary Liver Cancer 2022 or the American Association for the Study of Hepatology (AASLD) hepatocellular carcinoma.
- •Subjects who received radical excision or ablation (Radio Frequency Ablation (RFA) or Microwave Ablation (MWA) only) within 4 to 12 weeks prior to randomization (multiple modalities or combined or multiple treatments are not acceptable).
- •No major vena portae 3 (Vp3) or vena portae 4 (Vp4) in the portal vein or any level of vascular invasion in the hepatic vein or inferior vena cava.
- •No extrahepatic metastasis.
- •High risk factors for recurrence after radical resection or complete ablation.
- •Complete recovery from surgical resection or ablation within 4 weeks before randomization.
Exclusion Criteria
- •Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC histology.
- •Evidence of residual, recurrent, or metastatic disease at randomization.
- •More than one surgical treatment for hepatocellular carcinoma; Received more than 1 prophylactic Transcatheter Arterial Chemoembolization (TACE) treatment after surgery; or received Hepatic Artery Infusion Chemotherapy (HAIC) therapy after surgery.
- •Previous use of antiangiogenic drugs or PD-1, Programmed Cell Death-Ligand 1 (PD-L1) and other related immunotherapy drugs or systemic chemotherapy drugs.
Arms & Interventions
Anlotinib hydrochloride capsules + Penpulimab injection
Anlotinib hydrochloride capsules + Penpulimab injection, 21 days as a treatment cycle.
Intervention: Anlotinib hydrochloride capsules, Penpulimab injection
Anlotinib hydrochloride capsules -matching placebo+ Penpulimab injection -matching placebo
Anlotinib hydrochloride capsules -matching placebo+ penpulimab injection -matching placebo, 21 days as a treatment cycle.
Intervention: Anlotinib hydrochloride capsules -matching placebo, Penpulimab injection -matching placebo
Outcomes
Primary Outcomes
Recurrence-free survival (RFS)
Time Frame: Baseline up to 3 years.
RFS assessed by the Blinded Independent Image Review Committee and the investigator is the time from randomization to the first local, regional recurrence or distant metastasis, or death from any cause, whichever occurred first.
Secondary Outcomes
- Time to recurrence(TTR)(Baseline up to 3 years.)
- Time to extrahepatic metastasis or macrovascular invasion(Baseline up to 3 years.)
- Overall survival (OS)(Baseline up to 3 years.)
- Objective response rate (ORR) after first recurrence(Baseline up to 3 years.)