A study to investigate intermittent and continuous oxygen and ventilation support during physical activity in exertional hypoxemic COPD patients - Ventilation and oxygen support for COPD patients

Philips0 个研究点目标入组 13 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•Subjects eligible for participation should meet the following criteria:
•1. Patients with a diagnosis of COPD, which is spirometrically confirmed with FEV1/FVC ratio below 0.7 and staged as GOLD 2 or higher, which is FEV1 < 80% of predicted according to validated reference values.
•2. Age between 40 and 80 years.
•3. No hypoxia requiring long term oxygen treatment and no hypercapnia. Normal blood gases are defined as pO2 levels * 7.3 kPa and pCO2 levels below 6.5 kPa.
•4. Pulseoxymetre measured hemoglobin oxygen desaturation during 6 minute walking distance below 88%.
•5. Presence of static hyperinflation, measured as an increase in residual volume > 150% of predicte values according to validated reference values.
•6. Stable state COPD, which is free from exacerbations or respiratory infections for at least two weeks.
•7. Signed informed consent.

•Subjects eligible for participation should not meet the following criteria:
•1. Active malignancy
•2. Previous pulmonary surgery
•3. Unstable cardiovascular disease as unstable coronary artery disease, heartfailure or claudicatio intermittens as these might infere with the safety of the exercise.
•4. Orthopedic problems that interfere with walking tests
•5. Use of walking aids or wheel chair
•6. Contraindications for use of non-invasive ventilation: acute sinusitis or otitis media, low blood pressure, inability to adequately clear secretions, etc..

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