CTRI/2025/04/084440尚未招募不适用
Estimation of galectin-3 and tumor necrosis factor a levels in gingival crevicular fluid of periodontitis patients with and without obesity - An observational study
Dr Divya Shonima1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2025年4月21日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Galectin 3 and TNF alpha level in GCF
研究概览
简要总结
This study is an observational study assesing the levels of Galectin-3 and Tumor necrosis factor alpha in GCF of periodontitis patients with and without obesity . It will be conducted in The Oxford Dental College , Bangalore in India . The primary outcome measure will be Galectin-3 and TNF alpha levels in GCF . The secondary outcome measure will be clinical parameters - Gingival index, bleeding on probing, probing depth and clinical attachment loss . 36 GCF sample is taken from 12 subjects in each group and biomarker levels will be assessed using ELISA method .
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Subjects of either sex, between the age of 20 and 60 years 2) Presence of at least 20 natural teeth 3) Individuals with healthy periodontium of clinical parameters of bleeding on probing less than 10 % and probing depth less than or equal to 3 mm 4) Patients with diagnosis of generalised stage III grade B periodontitis with clinical parameters of probing depth more than or equal to 6 mm and clinical attachment loss more than or equal to 5 mm 5) Subjects with obesity having BMI values given by Asia Pacific Perspective Obesity.
- •WHO 2000 Non obese.
- •between range of 18.5 to 22.9 kg/m2 Obese.
- •between range of 25 to 29.9 kg/m2.
排除标准
- •Individuals with systemic diseases 2) Smokers 3) Pregnant/lactating and postmenopausal women 4) Individuals who have received periodontal therapy in the last 6 months 5) Individuals who have history of antimicrobial and anti-inflammatory therapy in the past 6 months.
结局指标
主要结局
Galectin 3 and TNF alpha level in GCF
时间窗: baseline
次要结局
- Clinical parameters - Gingival index, Bleeding on probing, Probing depth, Clinical attachment loss(baseline)
研究者
Dr Divya Shonima
The Oxford Dental College, Bangalore
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
Estimation and Correlation of ghrelin and TNF-alpha levels in GCF of Healthy individuals and Chronic generalized periodontitis individuals with and without obesityCTRI/2025/07/090127Kaustubh Ram60
招募中
不适用
Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of PreeclampsiaNCT07349277Ammar Jassim Abed120
尚未招募
不适用
Correlation Between Circulating Fibroblast Activation Protein (FAP) and Fibrosis in Two Diseases (Rheumatoid Arthritis and Systemic Sclerosis)NCT07393217Sohag University111
招募中
不适用
Exploring metabolic proteins in key signaling pathways in Type 2 diabetesCTRI/2025/11/097305Prof Nilanjan Saha252
已完成
不适用
α-N-acetylgalactosaminidase in Methamphetamine PsychosisNCT07434401Elazığ Mental Health and Diseases Hospital93