Observational Study of Exposure to Environmental Toxicants Among Firefighters

Recruiting

• Conditions: Healthy

• Registration Number: NCT05643014
• Lead Sponsor: Masonic Cancer Center, University of Minnesota

Brief Summary

Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-01
• Study First Submitted: 2022-11-30
• Study First Submitted QC: 2022-11-30
• Study First Posted: 2022-12-08
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-27
• Last Update Posted: 2025-02-28
• Primary Completion: 2025-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Firefighter (career or volunteer)
• Over 18 years of age
• Able to provide written voluntary consent

Exclusion Criteria

• Unwilling to provide a pre and post-exposure urine sample
• Current cancer diagnosis
• Tobacco use within the last 1 year (verified by urinary TNEs)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Studying biomarker levels in firefighters pre and post fire call.	48 months	The investigators will evaluate the differences between mean pre-exposure biomarker levels and post-exposure levels in urine and buccal samples collected within 24 hours post-exposure and 1-week post-exposure respectively using t-tests to test for statistical significance.

Trial Locations

Locations (1)

Masonic Cancer Center; 🇺🇸 Minneapolis, Minnesota, United States