A clinical trial intended to study the effect of drug dexmedetomidine in preventing agitation in adults after surgery under general anaesthesia
Phase 4
Completed
- Conditions
- Health patients without any comorbidities
- Registration Number
- CTRI/2018/02/012197
- Lead Sponsor
- Tejesh CA
- Brief Summary
This is a randomised, double blind, placebo controlled study to evaluate the efficacy of dexmedetomidine infusion at 0.4mcg/kg/hr from the beginning of induction till extubation for the prevention of emergence agitation in 100 ASA 1 & 2 adults aged 20-60yr undergoing nasal surgery under general anaesthesia. The primary outcome measure is the incidence of emergence agitation as assessed by Ricker sedation-agitation scale.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
American Society of Anaesthesiologists (ASA)grade 1 and 2 Patients undergoing nasal surgery under general anaesthesia and requiring nasal packing after surgery.
Exclusion Criteria
- Known or suspected allergy to α2 adrenergic agonists.
- Use of monoamine oxidase inhibitors, adrenergic blocking agents or clonidine.
- Uncontrolled hypertension and Diabetes mellitus.
- Heart block greater than first degree.
- Cognitive impairment.
- Chronic use of antipsychotic medications.
- Kidney or liver disease.
- Body Mass index ≥30kg/m² Pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Emergence agitation assessed by Ricker sedation-agitation scale Emergence agitation assessed by Ricker sedation-agitation scale immediately after extubation of the patient
- Secondary Outcome Measures
Name Time Method 1.Time to verbal response and extubation 2.Introperative analgesic requirement
Trial Locations
- Locations (1)
MS Rahaiah Hospital
🇮🇳Bangalore, KARNATAKA, India
MS Rahaiah Hospital🇮🇳Bangalore, KARNATAKA, IndiaTejesh CAPrincipal investigator9886481848drtejeshca@yahoo.com