Investigating imaging and clinical decision tools for identifying and ruling out subarachnoid haemorrhage in patients presenting with an acute severe headache to UK Emergency Departments

Not Applicable

• Conditions: Subarachnoid haemorrhage and acute severe headache; Circulatory System

• Registration Number: ISRCTN18417679
• Lead Sponsor: orthern Care Alliance

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-11-17
• Last Update Posted: 22 August 2022
• Study Completion: 2023-02-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 9000

Inclusion Criteria

1. Aged =18 years
2. Presenting with a non-traumatic acute headache that reaches maximal intensity within one hour to UK Emergency Departments (ED) or equivalent acute secondary care environment

Exclusion Criteria

1. Direct head trauma in the previous 7 days
2. Returning for reassessment of the same headache within the recruitment period
3. Established diagnosis of subarachnoid haemorrhage, brain neoplasm, ventricular shunt or hydrocephalus prior to attendance at the emergency department.
4. Focal neurological deficit
5. Headache with onset >14 days prior to attendance
6. Recurrent headaches defined as =3 headaches of similar character and intensity as presenting headache
7. Transfer from another hospital with confirmed subarachnoid haemorrhage
8. Prisoner presenting to ED/secondary care
9. Patient currently under detained Mental health act, presenting to ED/secondary care

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Current primary outcome measure as of 18/05/2021:<br> 1. External validation of a 6-hour CT brain rule out strategy for alert (defined as awake and fully orientated or GCS 15/15) patients presenting with acute non-traumatic headache, where there is clinical concern for SAH using prospectively collected data.<br><br> Previous primary outcome measure:<br> 1. External validation of the proposed 6 h CT brain rule out strategy for alert patients (defined as awake and fully orientated or GCS 15/15) presenting with acute non-traumatic headache, suggestive of subarachnoid haemorrhage using prospectively collected data<br>