Antimicrobial effect and penetration of silver from silver garments
Completed
- Conditions
- Atopic Dermatitis / Atopic Eczema10014982
- Registration Number
- NL-OMON38442
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1) Age between 18 and 55 years
2) Caucasian race of Western European origin
Exclusion Criteria
1) Systemic inflammation disease other than AD
2) Skin disease other than AD or contact eczema
3) Use of antihistaminics or inflammation-suppressing medication (e.g. corticosteroids, NSAIDs) or antibiotics one month prior to, and during the investigation
4) Sunbathing or using a tanning bed during 2 months prior to, and during the investigation
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The following parameters will be measured:<br /><br><br /><br>1. Total concentration and size of Ag particles in different layers of the<br /><br>stratum corneum harvested by adhesive tape stripping.<br /><br>2. Concentration of inflammatory mediators (including IL-1a, Il-1RA, and IL-8)<br /><br>in the stratum corneum harvested by adhesive tape stripping<br /><br>3. Concentration of Ag in urine<br /><br>4. Density of Staphylococcus aureus on the skin surface, sampled by using<br /><br>cotton swabs. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>