Experimental in vitro characterization of chronic thromboembolic pulmonary hypertension.
Completed
- Conditions
- chronic thromboembolic pulmonary hypertension1006447710037454
- Registration Number
- NL-OMON48197
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
PH patients diagnosed with pulmonary hypertension older than 18 years can be
included in this study. Cells will be only isolated from chronic thromboembolic
pulmonary hypertension (CTEPH) patients undergoing a pulmonary endarterectomy.
Blood will be drawn from CTEPH as wel as pulmonary arterial hypertension
patients and healthy controls
Exclusion Criteria
PH patients who are categorized in group 2, 3 and 5 of the WHO classes
pulmonary hypertension (PH), are excluded from this study. Blood from control
subjects are only considered as controls if they do not have PH and/or do not
do have any bleeding disorders or take any medication that acts on the
coagulation cascade.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main objective of this study is to investigate the role of the CTEPH<br /><br>endothelium in platelet adhesion and clot formation. Pulmonary arterial<br /><br>endothelial cells (ECs) will be characterized before and after interaction with<br /><br>peripheral blood under shear stress. Cellular phenotypes of PAECs from CTEPH<br /><br>patients are compared to PAECs from control subjects, and possible underlying<br /><br>mechanisms will be investigated based on gained results. </p><br>
- Secondary Outcome Measures
Name Time Method