Exploratory research on latent esophageal motility disorders in non-erosive gastroesophageal reflux disease (NERD) resistant to proton-pump-inhibitors (PPIs)
- Conditions
- non-erosive gastroesophageal reflux disease (NERD) resistant to proton-pump-inhibitors (PPIs)
- Registration Number
- JPRN-UMIN000021568
- Lead Sponsor
- Depertment of 2nd. internal medicine, Osaka Medical Collage
- Brief Summary
The subjects of the study were 100 patients who suffered from dysphagia; were examined and treated at Hospital between July 2011 and December 2013; had organic disease ruled out by upper gastrointestinal endoscopy; showed no alleviation of symptoms despite administration of the standard dose of a PPI for at least 8 weeks; were at least 20 years old; and were diagnosed as having PPI-resistant NERD. The mean age was 59.31years, and 45 males and 55 females were included, with mean ages of 58.80 and 59.73 years, respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Not provided
(i)Drug administration and/or endoscope insertion made difficult by constriction or deformation of the upper gastrointestinal tract. (ii)Suffering from active malignant tumors, or other serious, systemic complications. (iii)Suffering from active ulcers. (iv)Suffering from serious complications, such as heart, kidney, liver, or respiratory failure. (v)A history of treatment of the upper abdomen with radiotherapy. (vi)A history of surgical treatment of the gastrointestinal tract.
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The study was carried with patients who had been diagnosed as having PPI-resistant NERD, showed no erosive esophageal mucosal damage, and showed no alleviation of dysphagia symptoms after administration of standard doses of PPIs for at least 8 weeks. After enrolment, the presence or absence of esophageal motility disorder was evaluated on the basis of the Chicago classification, using HRM.
- Secondary Outcome Measures
Name Time Method Efficacy of the PPI for NERD