Genetics and Biology of Liver Tumorigenesis in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Biomarkers associated with hepatoblastoma subtypes and cancer stages
研究概览
简要总结
This research trial is studying biomarkers in tissue samples from young patients with liver cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
详细描述
PRIMARY OBJECTIVES:
I. To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA array profiling), and their potential correlation with liver developmental stages as well as outcome.
II. To correlate expression array data with copy number array data.
SECONDARY OBJECTIVES:
I. To carry out a focused sequencing interrogation of amplified or deleted genomic regions as well as genes in key cell pathways involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of hepatoblastoma or other liver cancer including the following subtypes:
- •Pure fetal histology
- •Transitional histology
- •Small cell undifferentiated histology
- •Participated on the Children's Oncology Group (COG) clinical trials
- •Available data and tumor samples
排除标准
- 未提供
结局指标
主要结局
Biomarkers associated with hepatoblastoma subtypes and cancer stages
时间窗: Baseline
次要结局
- Genes involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma(Baseline)
- Exome sequencing(Baseline)