Granulosa cell tumours: a step towards targeted therapy

Recruiting

• Conditions: granulosa cell tumour; Ovarian cancer; 10038594

• Registration Number: NL-OMON54607
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

Women (of any age)
o Diagnosed with a granulosa cell tumour (now or in the past) OR;
o Suspected of a GCT, scheduled for surgery

Exclusion Criteria

If histopathological examination after surgery shows a diagnosis other than a
granulosa cell tumour, this patient will be excluded and will not be followed
during the study period.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoint of the proposed investigation is the identification of novel<br /><br>therapeutic targets in granulosa cell tumours, by first identifying common<br /><br>mutations or other genetic alterations and subsequently performing drug screens<br /><br>in tumour organoid cell cultures to study the effect of targeting the observed<br /><br>aberrations in human granulosa cell tumour samples. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The presence of circulating tumour DNA (ctDNA) in plasma of granulosa cell<br /><br>tumour patients, and its value as a diagnostic marker for tumour load.</p><br>