Randomized, placebo-controlled, double-blind comparative study of N-Acetylcysteine for the treatment with intervertebral disc degeneration.
Not Applicable
Completed
- Conditions
- umbar intervertebral disc degeneration associated with low back pain (containing lumbar disc herniation)
- Registration Number
- JPRN-UMIN000032378
- Lead Sponsor
- Keio University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1) Severe combined complications of heart, liver and blood diseases. 2) Patients with surgical treatment that attending physician consider having impact on the results. 3) Three times higher of AST/ALT before administration of NAC 4) Currently taking NAC or supplement containing NAC. 5) Allergy for NAC 6) Women who are during pregnancy, under lactation, have a possibility to pregnancy, and who hope pregnancy. 7) Previous spine surgery 8) Incompetent patients judged by attending doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie N-Acetylcysteine's effect on intervertebral disc degeneration and low back pain?
How does N-Acetylcysteine compare to standard-of-care treatments for lumbar disc herniation in clinical trials?
Are there specific biomarkers that predict response to N-Acetylcysteine in patients with intervertebral disc degeneration?
What are the known adverse events associated with N-Acetylcysteine therapy for disc degeneration and how are they managed?
What combination therapies or competitor drugs show promise for treating lumbar intervertebral disc degeneration alongside N-Acetylcysteine?