Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 2,000
- 试验地点
- 2
- 主要终点
- Stroke.
研究概览
简要总结
The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.
详细描述
To assess outcomes after cardiac surgery procedures. To investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ischemic heart disease with indications for operation
- •valve disease with indications for operation
- •ischemic heart disease combined with valve disease with indications for operation
排除标准
- •patient refusal
结局指标
主要结局
Stroke.
时间窗: within 30 days after procedure.
Stroke (MRI changes or corresponding neurologist record).
Infection or febrile.
时间窗: within 30 days after procedure.
Infection or febrile (t\> 37 or CRP elevation or long regeneration of surgical wound).
Respiratory dysfunction.
时间窗: within 30 days after procedure.
Respiratory dysfunction (pulmonary ventilation longer than 2 days).
Death within 30 days after procedure.
时间窗: within 30 days after procedure.
Death within 30 days after surgical procedure.
Acute myocardial infarction.
时间窗: within 30 days after procedure.
Acute myocardial infarction (ST-changes with troponin I \> 10 ng/ml).
Renal dysfunction.
时间窗: within 30 days after procedure.
Renal dysfunction if serum creatinine greater than 25% of upper reference range.
Arrhythmia
时间窗: within 30 days after procedure.
Any type of arrhythmia including AV-block.
次要结局
未报告次要终点
研究者
Aleksandr Nemkov
PhD
St. Petersburg State Pavlov Medical University