Randomized, Open Label, Active Control, Parallel Assignment Clinical Trial to Evaluate the Immunogenicity of Polysaccharide Meningococcal C Vaccines Conjugated With Tetanus Toxoid or CRM197 Given as a Booster Dose at 14-18 Months of Life.
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Meningococcal Infection
- Sponsor
- Centro Superior de Investigación en Salud Publica
- Enrollment
- 389
- Locations
- 2
- Primary Endpoint
- Serum Antibody Titers Against Haemophilus Influenzae Type b.
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of the study is to evaluate the immune response of toddlers, to a booster dose in the second year of life of two meningococcal C conjugated polysaccharide vaccine, and to assess the interchangeability of the two different vaccines.
Detailed Description
Children 14 to 18 months of life, previously vaccinated with 2 doses of tetanus toxoid conjugated polysaccharide men C vaccine or three doses of the CRM197 conjugated polysaccharide men C vaccine before 7 months of age, are randomized to receive any of the two vaccines. Serum antibody activity against meningococcus C will be measured inmediately before and 4 weeks after the booster dose. Children will also be vaccinated with a combined vaccine containing DTaP+IPV+Hib.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy toddlers of both sexes
- •Toddlers of 14 to 19 months of age (including the day that the toddler is 14 and the day before he is 19 months of age)
- •Children previously vaccinated with two doses of polysaccharide meningococcal C vaccine conjugated to tetanus toxoid or three doses of polysaccharide meningococcal C conjugated to CRM197 before 7 month of age.
- •Informed consent signed by one or both parents who are adequately informed about the study.
Exclusion Criteria
- •Toddlers with severe diseases or axilar temperature ≥ 38,0ºC at inclusion time
- •Toddlers with severe chronic diseases
- •Toddlers who have received any other vaccine within the last month or with a programmed vaccination within the 28 subsequent days after the administration of the vaccine of study.
- •Toddlers with clinical or bacteriological diagnosis of previous meningococcal disease.
- •Toddlers with hypersensitivity to any of the components of the vaccines to study or antibiotics used during the manufacturing process that could be present as non- detectable traces (streptomycin, neomycin, polymyxin B).
- •Toddlers with personal history of convulsions.
- •Toddlers with known bleeding disorder no controlled
- •Toddlers with known congenital or acquired immunodeficiency
- •Toddlers who are receiving or have been received any treatment that could change the immune response (administration of intravenous immunoglobulin, systemic corticosteroids or haemoderivates) within the 3 previous months.
- •A toddler that under investigator opinion is probable to be lost during the follow-up
Outcomes
Primary Outcomes
Serum Antibody Titers Against Haemophilus Influenzae Type b.
Time Frame: One year
Serum Bactericidal Activity Against MenC
Time Frame: One month after booster dose