A prospective observational study to elucidate the dynamics of microparticles and their pathophysiological role in septic disseminated intravascular coagulation syndrome.
Not Applicable
- Conditions
- sepsis
- Registration Number
- JPRN-UMIN000044745
- Lead Sponsor
- Tohoku University Hospital department of Anesthesiology and preoperative medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1) Cases for which consent was not obtained from the patient or the patient's next of kin 2) Patients requiring mechanical assisted circulation (IABP, ECMO, LVAD) 3) Patients requiring acute blood purification therapy prior to the start of the study 4) Patients with infection more than 7 days prior to study enrollment or with unknown onset of infection 5) Pregnant
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint was the amount of Tissue factor bearing microparticles (TF banding MPs) at the first blood draw in the DIC and non-DIC groups.
- Secondary Outcome Measures
Name Time Method Comparison of the production of other MPs (monocyte-derived, endothelial cell-derived, platelet-derived, etc.) between DIC and non-DIC groups. Thrombin generation study.