Endoscopic Surveillance Comparing Narrow Band Imaging (NBI) Against Lugol Chromoendoscopy for Detection of Synchronous Superficial Squamous Esophageal Neoplasia Among High Risk Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Superficial Esophageal Neoplasia
- Sponsor
- Chinese University of Hong Kong
- Enrollment
- 180
- Primary Endpoint
- Diagnostic accuracy of superficial esophageal neoplasia
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study aimed to compare Narrow Band Imaging (NBI) against Lugol chromoendoscopy for diagnosis of early esophageal cancers among high risk patients.
Detailed Description
The investigators recruited consecutive patients with head and neck cancers, history of squamous esophageal cancers treated by chemoradiotherapy or endoscopic resection. Endoscopic surveillance first started with NBI for detection and characterization of early esophageal cancers through observation of abnormal intrapapillary capillary loops (IPCL). Superficial esophageal neoplasia were diagnosed by IPCL Type IV, V1,V2 and Vn. Lugol chromoendoscopy would be performed subsequently and suspicious neoplasia were classified as understain or unstain lesions. The diagnostic accuracy, sensitivity and specificity of NBI were compared to Lugol chromoendoscopy with histology serving as a gold standard.
Investigators
Philip Wai Yan Chiu
Professor
Chinese University of Hong Kong
Eligibility Criteria
Inclusion Criteria
- •Patients with Head and Neck Cancer
- •Patients with esophageal cancer treated by chemoradiotherapy and in remission for 2 years
- •Patients with esophageal cancer treated by endoscopic resection
- •Age 18 to 80
Exclusion Criteria
- •Allergy to Lugol iodine
- •Previous esophagectomy
Outcomes
Primary Outcomes
Diagnostic accuracy of superficial esophageal neoplasia
Time Frame: 1 month