Diagnostic Values of C-reactive Protein and Procalcitonin in Predicting Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

• Conditions: Chronic Obstructive Pulmonary Disease
• Interventions: Diagnostic Test: C- reactive protein; Diagnostic Test: Pro calcitonin

• Registration Number: NCT03923803
• Lead Sponsor: Assiut University

Brief Summary

Chronic obstructive pulmonary disease is a serious disease . Exacerbations of Chronic obstructive pulmonary disease is an acute worsening condition of Chronic obstructive pulmonary disease, which always accompanied by clinical symptoms such as, shortness of breath and increased production of sputum. Respiratory infection (bacteria or viruses or mixed) is thought to be the main cause in most exacerbations.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-04
• Study First Submitted: 2019-04-18
• Study First Submitted QC: 2019-04-18
• Last Update Submitted: 2019-04-18
• Study First Posted: 2019-04-23
• Last Update Posted: 2019-04-23
• Study Start: 2019-07
• Primary Completion: 2020-06
• Study Completion: 2020-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients admitted to the hospital

Exclusion Criteria

• patients with malignancies
• patients with other systemic infection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Chronic obstructive pulmonary disease	C- reactive protein	patients with acutely exacerbated Chronic obstructive pulmonary disease admitted in chest department Assiut university hospital ,30 patients who revealed sputum culture and inflammatory markers suggesting infection exacerbation will be followed up
Chronic obstructive pulmonary disease	Pro calcitonin	patients with acutely exacerbated Chronic obstructive pulmonary disease admitted in chest department Assiut university hospital ,30 patients who revealed sputum culture and inflammatory markers suggesting infection exacerbation will be followed up

Primary Outcome Measures

Name	Time	Method
The level of C-reactive protein between Infection and Non-infectious inflammatory response in acute exacerbations of Chronic obstructive pulmonary disease patients	24 hours	Patients will be classified into cases with Infection or non-infectious inflammatory response according to the level of C-reactive protein