Clinical Pharmacology Study of CS-3150 Drug-drug interaction study between CS-3150 and amlodipine in healthy Japanese subjects

In study 1, the pharmacokinetics of esaxerenone was not affected by amlodipine when esaxerenone 2.5 mg was coadministered with amlodipine 10 mg. In study 2, AUC for amlodipine was increased by approximately 1.2 fold, but Cmax for amlodipine was not increased when amlodipine 2.5 mg was coadministered with esaxerenone 5 mg. It was considered that there were no safety concerns when esaxerenone was administered concomitantly with amlodipine.