Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair
Terminated
- Conditions
- Traumatic Brain Injury
- Registration Number
- NCT00336726
- Lead Sponsor
- Denver Research Institute
- Brief Summary
Traumatic Brain Injury (TBI) is a neurologic disorder cuased by physical trauma to the brain. Neuroendocrine abnormalities in these patients have been reported, including central hypogonadism within hours of the insult and eventual recovery of the hypothalamic-pituitary-gonadal axis with recovery of cognitive function to baseline. This pilot study will measure hormonal level of neuroendocine function at the time of TBI and various time points during recovery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
- Male subjects having had a recent traumatic brain injury.
Exclusion Criteria
- Currently receivng sex steroids, glucocorticoids, or have an inability to complete the neurobehavioral assessment.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link neuroendocrine dysfunction to cognitive recovery in traumatic brain injury patients?
Are there specific biomarkers that correlate with hypothalamic-pituitary-gonadal axis recovery after TBI?
How does neuroendocrine disruption in TBI compare to other neurodegenerative conditions like Alzheimer's disease?
What are the potential adverse events associated with neuroendocrine system recovery post-TBI and their management strategies?
What combination therapies show promise in addressing both neuroendocrine and cognitive impairments following TBI?