The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders

Completed

• Conditions: Generalized Chronic Periodontitis; Pulmonary Disease, Chronic Obstructive
• Interventions: Genetic: SERPINA1 gene

• Registration Number: NCT02498938
• Lead Sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Brief Summary

Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.

Detailed Description

periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase

COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.

SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.

Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2015-07-13
• Study First Submitted QC: 2015-07-14
• Study First Posted: 2015-07-15
• Primary Completion: 2015-11
• Study Completion: 2015-12
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-26
• Last Update Posted: 2016-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.

Read More

Exclusion Criteria

• Pateints with other systemic disorders
• patients not willing to participate in the study

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
SERPINA1 gene in COPD and periodontitis	SERPINA1 gene	patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (\>4mm pocket probing depth)

Primary Outcome Measures

Name	Time	Method
SERPINA1 gene polymorphism	9 months	of blood samples and running samples by PCR

Trial Locations

Locations (1)

Dr. Sneha Agarwal PG(periodontics); 🇮🇳 Hyderabad, Telangana, India