Correlation Between Pupil Size and Ocular Signs of Pseudoexfoliation Syndrome

Completed

• Conditions: Pseudoexfoliation of Lens; Glaucoma; Pseudoexfoliation Syndrome; Pseudoexfoliation Glaucoma in Both Eyes

• Registration Number: NCT05113121
• Lead Sponsor: Assiut University

Brief Summary

To study possible correlation between the size of the pupil in both room light and after dilation between both eyes in bilateral pseudoexfoliation with Intraocular pressure, lens clarity and stability, Optic disc , Visual changes and glaucoma changes by optical coherence tomography

Detailed Description

For each patient. Full preoperative ophthalmological assessment will be done using slit lamp , size of the pupil in regular room light (usually around 2000 Lux) and post dilation with tropicamide 1%. baseline IOP measurement using Goldmann applanation tonometer, UCDVA (Uncorrected Distance Visual Acuity)and CDVA (Corrected Distance visual acuity), lens opacification or clarity, stability or subluxation. corneal endothelial cell count. Fundus examination using 90 D or 78D lenses, Humphrey visual field (24-2) analysis and optical coherence tomography on retinal nerve fiber layer (RNFL) and ganglion cell complex.(GCC)

Study Timeline

• Study Start: 2021-08-25
• Study First Submitted: 2021-10-28
• Study First Submitted QC: 2021-10-28
• Study First Posted: 2021-11-09
• Primary Completion: 2022-01-11
• Study Completion: 2022-02-10
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-09
• Last Update Posted: 2022-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

All patients with pseudoexfoliation syndrome

Exclusion Criteria

previous ocular surgery or ocular trauma affecting pupil. Any systemic or neurologic disease affecting pupil

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
correlation between pupil size and severity of Pseudoexfoliation	2-3 months	in each eye of the same patient we study correlation between pupil size with ntraocular pressure, lens status, corneal endothelial count and glaucomatous damage represented by (optic disc changes (cup to disc ratio) and OCT changes (RNFL and GCC)

Trial Locations

Locations (1)

Assiut University; 🇪🇬 Assiut, Egypt