The Effect of Berry Extract on Helicobacter Pylori Eradication
- Conditions
- Increase the Eradication Rate of Helicobacter Pylori
- Interventions
- Dietary Supplement: Berry extract
- Registration Number
- NCT01045408
- Lead Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
- Brief Summary
Helicobacter pylori (HP) is the major risk factors of gastritis, gastric ulcers, duodenal ulcers, mucosa associated lymphoid tissue lymphoma and gastric cancer. Helicobacter pylori are found in 70-90% of the population in developing countries and in 25-50% of developed countries.
- Detailed Description
One-week of triple therapy composed of a proton pump inhibitor plus two antibiotics is currently regarded as the gold standard for HP eradication. However, the eradication rate continues to be disappointing. Poor patient compliance and bacterial resistance are the main factors contributing to treatment failure. Therefore, it is urgently necessary to develop a non-antibiotic alternative therapy to increase the eradication rates of Helicobacter pylori. Some literatures reported that cranberry may inhibit Helicobacter pylori adhesion to the human gastric mucus and may reduce Helicobacter pylori infection in adults. The aims of his experiment were to explore the impact of berry extract on triple therapy for Helicobacter pylori eradication.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- Patients older than 18
- Pregnancy or breastfeeding
- Use of antibiotics 2 weeks prior to inclusion
- Previous eradication treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Berry extract - Berry Berry extract -
- Primary Outcome Measures
Name Time Method Eradication rate 4 weeks after Eradication of Helicobacter pylori
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Shin Kong Wu Ho-Su Memorial Hospital
🇨🇳Taipei, Taiwan