Pediatric Ards Neuromuscular blockade (PAN) study: Life-threatening acute respiratory failure in children: to breathe or not to breathe spontaneously, that's the question. A multicentre, randomised, double-blind, placebo controlled study. - PAN study

niversitair Medisch Centrum Groningen0 个研究点目标入组 178 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- Informed consent
•- Age younger than 5 years
•- Need for invasive mechanical ventilation with PEEP 5 cmH2O
•- Early moderate - to - severe paediatric acute respiratory distress syndrome originating from any cause:
•* Acute onset of disease, and
•* Oxygenation index > 12, and
•* One or more (bilateral) infiltrates on chest radiograph, and
•* No evidence of left ventricular failure or fluid overload, and
•* Within the first 96 hours of PICU admission
•- Arterial line or central venous line present

•- No informed consent
•- Known allergy or intolerance to rocuronium
•- Continuous administration of neuromuscular blockade prior at the time of meeting the criteria for paediatric acute respiratory distress syndrome
•- Bolus administration of neuromuscular blockade within 1hr before meeting the criteria for paediatric acute respiratory distress syndrome
•- Chronic respiratory failure on home ventilation
•- Intracranial hypertension
•- Bone marrow transplantation
•- Pre-existing pulmonary hypertension
•- Congenital heart disease with left - to - right shunting
•- Cyanotic congenital heart disease
•- (Suspected) underlying neuromuscular or metabolic disorder
•- Expected duration of mechanical ventilation less than 48 hours
•- Withdrawal of life-sustaining treatment or other treatment limitations

发起方