Pharmacological Treatment of Depression.
Completed
- Conditions
- This is a double blind, randomized study with a washout period, comparing 2 treatments strategies.Study duration is 1 week washout period, 7 weeks acute treatment and continuation treatment of responders during 4 months.<br />One condition is with imipramine with adequate plasma levels the other is venlafaxine with optimal dosage
- Registration Number
- NL-OMON22391
- Lead Sponsor
- Erasmus MC
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 138
Inclusion Criteria
For inclusion in the trial, patients must fulfill all of the following criteria:
1. Age 18-65;
Exclusion Criteria
Any of the following is regarded as a criterion for exclusion from the trial:
1. Patients whom are incapable to understand the information and to give informed consent. And patients whom are unable to read or write;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in HRSD scores.
- Secondary Outcome Measures
Name Time Method 1. Change in CGI scores;<br /><br>2. Response defined as > 50% reduction on HRSD compared to baseline;<br /><br>3. Remission defined as an end score of < 7 on the HRSD.