Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections
Not Applicable
Completed
- Conditions
- Liver Function
- Interventions
- Drug: Intravenous normal saline (NS 0.9)Drug: dextrose 10% (D10W ®) infusionDrug: hyperinsulinemic normoglycemic clampDietary Supplement: high calorie diet 35 kcal/kg
- Registration Number
- NCT00774098
- Lead Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Brief Summary
We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- 18 years or older
- planned to undergo a major liver resection at McGill University Health Center (MUHC)
Exclusion Criteria
- patients known with chronic viral liver disease
- uncontrolled or type one diabetes mellitus (DM)
- patients on oral beta-blocker agents
- patients with unresectable disease determined intra-operatively
- patients unable to give consent for the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Group Intravenous normal saline (NS 0.9) Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output GICP dextrose 10% (D10W ®) infusion - GICP hyperinsulinemic normoglycemic clamp - GICP high calorie diet 35 kcal/kg -
- Primary Outcome Measures
Name Time Method Postoperative liver function test Postoperative
- Secondary Outcome Measures
Name Time Method Liver and muscle glycogen, TG, and protein content at beginning and end of the procedure. Begining + end of the procedure Incidence of complications Postoperative
Trial Locations
- Locations (1)
Royal Victoria Hospital
🇨🇦Montreal, Quebec, Canada