Propensity Score Matched Comparison of HMP vs. SCS in Kidney Transplantation

Completed

• Conditions: Delayed Graft Function

• Registration Number: NCT04359173
• Lead Sponsor: Medical University Innsbruck

Brief Summary

Hypothermic machine perfusion (HMP) is considered superior to static cold storage (SCS) in kidney transplantation, but the true benefit in the real-world experience remains incompletely understood.

The aim of our study is to investigate the real-world impact of HMP on kidney graft function after deceased donor kidney transplant in an HMP cohort propensity score matched with SCS.

Propensity score matching will be based on CIT, ECD, gender mismatch, CMV mismatch, re-TX and ET-senior program with a caliper of 0.05

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08-01
• Primary Completion: 2019-12-31
• Study Completion: 2020-03-30
• Status Verified: 2020-04
• Study First Submitted: 2020-04-20
• Study First Submitted QC: 2020-04-22
• Last Update Submitted: 2020-04-22
• Study First Posted: 2020-04-24
• Last Update Posted: 2020-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 347

Inclusion Criteria

• single kidney transplantation from a deceased donor at Medical University of Innsbruck between 08/2015 and 12/2019

Exclusion Criteria

• combined kidney transplantation with an other organ
• living donor kidney transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delayed graft function (DGF)	7 days post transplant	DGF was defined as the need for at least one dialysis within the first seven days after transplant with the exception of dialysis for hyperkalemia or hypervolemia within the first 12 hours post-transplant

Secondary Outcome Measures

Name	Time	Method
graft survival	24 months post transplant	24 month graft survival

Trial Locations

Locations (1)

Medical University of Innsbruck; 🇦🇹 Innsbruck, Tyrol, Austria