The psychosocial impact of haematopoietic stem cell donation on adult related donors

Active, not recruiting

• Conditions: Haematopoietic stem cell donation; Psychosocial distress; Unmet needs; Quality of life; Public Health - Health service research; Blood - Haematological diseases; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12617000407392
• Lead Sponsor: niversity of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-03-20
• Last Update Posted: 12 November 2018

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

Update
Group 1: Adult related stem cell transplant donors of planned allogeneic transplant recipients.
Group 2: Adult related lymphocyte donors of planned lymphocyte infusion recipients.
Group 3: BMT Nurses within the RBWH and Westmead Hospital Haematology and Bone Marrow Transplant Units.

1) Ages eligible for study: 18 to 70 years
2) Able to provide informed consent

Exclusion Criteria

People whose primary language is other than English
Women who are pregnant and the human fetus
Children and/or young people (ie. <18 years)
People with a cognitive impairment, an intellectual disability or a mental illness

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Phase I<br>Psychological distress will be measured using the Kessler Psychological Distress Scale (K10)[(1) 2 weeks pre-stem cell collection; <br>(2) on the day of stem cell collection; <br>(3) 30 days post-stem cell collection];Phase I<br>Health-related quality of life will be measured using the World Health Organisation Quality of Life (WHOQOL-BREF); an abbreviated version of the WHOQOL-100.[(1) 2 weeks pre-stem cell collection; <br>(2) 30 days post-stem cell collection];Phase I<br>Saliva will be collected using Salivettes and analysed for salivary alpha-amylase activity (biomarker for activity of the sympathetic nervous system) by a liquid handling platform (the Beckman Coulter AU-480).[(1) 2 weeks pre-stem cell collection; <br>(2) on the day of stem cell collection; <br>(3) 30 days post-stem cell collection]