Effect of L-Carnitine on QT-Dispersion of patients with acute myocardial infarction in Rafsanjan Ali Ibn-Abitaleb Hospital: A randomized, double-blind, placebo-controlled trial
- Conditions
- Patients with acute myocardial infarction.ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction
- Registration Number
- IRCT20190128042525N3
- Lead Sponsor
- Rafsanjan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 200
Patients with Acute Myocardial Infarction with History, Examination, ECG and Cardiac Enzymes and Angiography
Patients undergoing angiography have more than 80% coronary stenosis
The type and extent of MI and age restriction are not relevant in this study.
Moderate and severe valvular disease
Pregnancy
Left and right bundle branch block
Patients taking vitamin supplements
Patients taking QT prolonging drugs (amiodarone, sotalol, quinidine, azithromycin, clarithromycin, erythromycin)
Underlying diseases such as diabetes (due to the effect of diabetes-induced oxidative stress on the antioxidant effects of L-carnitine) and liver failure (due to hepatic drug metabolism), and chronic renal failure grade 4 and 5 (GFR <30 mL / min / 1.73)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In the study Effect of oral L-carnitine tablets on QT-dispersion in patients with acute myocardial infarction hospitalized at Ali Ibn Abi Talib Hospital in Rafsanjan the primary outcome could be reduced QT-dispersion. Timepoint: In the study Effect of oral L-carnitine tablets on QT-dispersion in patients with acute myocardial infarction hospitalized in Hazrat Ali Ibn Abi Talib Hospital in Rafsanjan is the timing of measurement of QT-dispersion in the first day of study and last day. Method of measurement: The Method of measurement: how to measure the outcome variable: QT-dispersion is calculated by measuring the difference between the largest and the smallest QT. Interval in 12-lead of Electrocardiogram.
- Secondary Outcome Measures
Name Time Method