Typological Study of Sleep Pathologies During Psoriatic Rheumatism and SAPHO Syndrome: Prospective Study Within the Paris Saint-Joseph Hospital Group"

Recruiting

• Conditions: Psoriasis Arthritis; SAPHO Syndrome; Sleep Apnea Syndromes

• Registration Number: NCT07086599
• Lead Sponsor: Fondation Hôpital Saint-Joseph

Brief Summary

Chronic inflammatory rheumatisms (CIR) are a source of motor disability and various comorbidities, particularly cardiovascular and metabolic. They also significantly impact patients' quality of life, including sleep disturbances. Among CIRs, psoriatic arthritis is a chronic inflammatory arthropathy associated with psoriasis, typically seronegative for rheumatoid factor. This heterogeneous disease affects peripheral and/or axial joints and can include extra-articular manifestations such as uveitis and chronic inflammatory bowel diseases. Its prevalence is estimated between 0.3% and 1% in the general population.

SAPHO syndrome, similar to psoriatic arthritis, is characterized by specific bone involvement with a hypertrophic tendency, often affecting the axial skeleton and the anterior thoracic wall. Pain and inflammation are closely linked to sleep quality, creating a vicious cycle where pain disrupts sleep and poor sleep amplifies pain perception. Analgesic treatments, such as opioids, can also cause nocturnal respiratory pathologies, further disrupting sleep.

Inflammatory processes are regulated by sleep, influencing plasma concentrations of CRP, IL6, and TNF production. Patients with psoriatic arthritis or SAPHO syndrome share common risk factors with Obstructive Sleep Apnea Syndrome (OSAS), such as obesity, hypertension, and metabolic syndrome.

Sleep disorders are common in the general population and likely underdiagnosed in these patients. Several studies suggest a link between sleep disorders and these rheumatic conditions, affecting quality of life and exacerbating symptoms. Questionnaires like the Epworth and Pichot scales provide a more precise evaluation of these symptoms. However, objective sleep exploration through polysomnography has never been conducted in these patients.

In summary, CIRs, particularly psoriatic arthritis and SAPHO syndrome, significantly impact patients' quality of life and sleep, necessitating appropriate evaluation and management of associated sleep disorders.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-13
• Status Verified: 2025-07
• Study First Submitted: 2025-07-18
• Study First Submitted QC: 2025-07-18
• Last Update Submitted: 2025-07-18
• Study First Posted: 2025-07-25
• Last Update Posted: 2025-07-25
• Primary Completion: 2027-05-13
• Study Completion: 2027-11-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patient aged 18 years or older
• Patient diagnosed with psoriatic arthritis or SAPHO syndrome and followed at Paris Saint-Joseph Hospital
• Patient presenting sleep disorders warranting hospitalization for further -investigation of these disorders
• French-speaking patient
• Patient who does not oppose participation in the research protocol

Exclusion Criteria

• Patient already followed for a sleep disorder
• Patient who underwent polysomnography in the last 2 years
• End-of-life patient
• Patient under guardianship or curatorship
• Patient deprived of liberty
• Patient under legal protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Type of sleep disorders	at 6months	sleep disorders will be defined after polysomnography exam.

Secondary Outcome Measures

Name	Time	Method
sleep structure	at 6 months	quantity of the different sleep stages as observed on the polysomnography exam
presence and severity of asthenia,	at enrollement	mesured by the PICHOT questionnar
evaluation of anxiety	at enrollement	mesured by HAD questionnaire
drowsiness evaluation	at enrollement	mesured with the Epworth Scale
Evaluation of Sleep Apnea	at enrollement, at 6months and at 12 months	mesured with the STOP BANG questionnaire
Sleep apnea severy	at enrollemnt, 6months and 12 months after	mesured by the Apnea/hypopnea index
Rheumatism disease activity	at enrollement, after 6 months and after 12 months	mesured with the DPASA score
CRP mesurement	at enrollment, 6months and 12 months after	expressed in mg/L

Trial Locations

Locations (1)

Hôpital Paris Saint Joseph; 🇫🇷 Paris, France