Magnetic resonance imaging (MRI) for assessing fetal and neonatal brain development in the YOUth Cohort.
Recruiting
- Conditions
- Hersen-, neurocognitieve- en gedragsontwikkelingbehaviorbrain
- Registration Number
- NL-OMON55467
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Subject is included in the YOUth Cohor study, has a good understanding of the
Dutch language and has signed informed consent.
Exclusion Criteria
Subject meets any of the exclusion criteria of the YOUth Cohort study. Subject
and partner do not wish to be informed about unexpected fetal or neonatal MRI
findings with therapeutic consequences. Subjects are not willing to provide
informed consent. Subject experiences problems during the MRI scan or does not
adhere to instructions of the MRI team.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>A comprehensive examination of the developing brain will be carried out using<br /><br>T1, T2, DTI, SWI, PC-MRI and fMRI-derived (micro)structural and functional<br /><br>parameters: brain volumes, cortical thickness, cortical folding, white matter<br /><br>connectivity, hemodynamics and functional networks.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Structural and functional parameters of the developing brain will be linked to<br /><br>long-term neurocognition and behavioral outcome, i.e. behavioral control and<br /><br>social competence as examined in the YOUth Cohort.</p><br>