High-fat Meal Challenge in Pediatrics
Not Applicable
Completed
- Conditions
- Pediatric ObesityInsulin Resistance
- Registration Number
- NCT05230433
- Lead Sponsor
- Dartmouth-Hitchcock Medical Center
- Brief Summary
The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Children ages 8-17 years with a BMI-percentile ≥ 5th.
Exclusion Criteria
- Previous diagnosis of type 1 or 2 diabetes.
- Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin).
- Evidence of inherited disorders of lipid metabolism.
- Inability to participant in the maximal aerobic capacity test on the treadmill.
- Allergies to palm oils or protein types within high-fat challenge, such as lactose and soy.
- Individuals who cannot speak and/or write in English.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Palatability of the High Fat Agent. 10 minutes Determine the number of participants that complete at least 75% of the shake (by weight).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dartmouth-Health
🇺🇸Lebanon, New Hampshire, United States
Dartmouth-Health🇺🇸Lebanon, New Hampshire, United States